Divining God's mutation rate
نویسنده
چکیده
The total genomic mutation rate (μ) and the deleterious mutation rate ( U ), are of fundamental importance to a number of areas of biology, including the classic evolutionary conundrum: why sex? Unfortunately, both μ and U have historically proven extremely difficult to measure accurately. A recent study by Haag-Liautard et al. (1) combines traditional experimental ’mutation accumulation’ methods with whole-genome mutation screening to estimate μ and U in D. melanogaster. The high average value of U (∼1.2) suggests that deleterious mutations may play an important role in the maintenance of sexual reproduction. Interestingly, the overall mutation rate μ varied significantly among starting genotypes, reinforcing the idea that the mutation rate itself may potentially be fine-tuned by natural selection. An analogous study in the nematode C. elegans reported a similar value of U (2), consistent with the suggestion that the deleterious mutation rate has evolved close to a global optimum value (42). The imminent availability of extremely highthroughput DNA sequencing promises to allow biologists to understand global and local factors underlying ’the’ mutation rate.
منابع مشابه
Usefulness and safety of the "God's Hand" pneumatic compression device for hemostasis in femoral catheterization.
PURPOSE We aimed to assess the usefulness and safety of the God's Hand pneumatic compression device for hemostasis in patients undergoing percutaneous endovascular procedures via femoral artery. METHODS Two hundred thirty-seven patients in whom hemostasis of femoral catheterization was achieved using a God's Hand pneumatic compression device were enrolled. The patients were divided into group...
متن کاملThe Divining Reader: A Construct Based on the Bibliomantic Approach to Hafez’s Divan
Hafez Shirazi was a distinguished Persian poet. His poetry collection, Divan, is regarded as a literary work of profound significance. Iranians view this collection as something much more than poetry because it is also used for bibliomantic purposes. After studying Hafez in his social context and exploring distinctive qualities of his Divan, particularly its application as a divination tool, th...
متن کاملTerminal values as predictors of religious experience in the lives of married couples and singles
The aims of the research I embarked on were: (a) to show the preference of terminal values in personal and in social character as well as the level of religious experience: God's presence and God's absence among singles and married couples; and (b) to show the relation between terminal values in personal and in social character and religious experience: God's presence and God's absence in two g...
متن کاملGod will forgive: reflecting on God's love decreases neurophysiological responses to errors.
In religions where God is portrayed as both loving and wrathful, religious beliefs may be a source of fear as well as comfort. Here, we consider if God's love may be more effective, relative to God's wrath, for soothing distress, but less effective for helping control behavior. Specifically, we assess whether contemplating God's love reduces our ability to detect and emotionally react to confli...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2007